You might be having some Internet Connection issues.The firewall may be preventing the Client to run.However, we can predict some common reasons that can be stated for the League of Legends client not opening issue on Windows 10. There are no specific reasons for the issue, though these two are the most common scenarios Windows 10 users face. That is, nothing is shown in the window and the game does not start. The other is when you double-click on the game nothing happens at all.This means the League client not opening. One is when you try to play the game by double-clicking on the LOL client, there is a small pop up and the game does not start.